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Artsen en medewerkers - Publicaties

Prof. Dr. Wim Robberecht

2013

Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats.
Herdewyn S, De Muynck L, Van Den Bosch L, Robberecht W, Van Damme P
Neurobiol Aging; 2013 Apr 19;
The changing scene of amyotrophic lateral sclerosis.
Robberecht W, Philips T
Nat Rev Neurosci; 2013 Mar 6;
Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke.
Lemmens R, Jasper T, Robberecht W, Thijs VN
Hum Mol Genet; 2013 Feb 14;
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis.
Philips T, Bento-Abreu A, Nonneman A, Haeck W, Staats K, Geelen V, Hersmus N, Küsters B, Van Den Bosch L, Van Damme P, Richardson WD, Robberecht W
Brain; 2013 Jan 31;
Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.
Taes I, Timmers M, Hersmus N, Bento-Abreu A, Van Den Bosch L, Van Damme P, Auwerx J, Robberecht W
Hum Mol Genet; 2013 Jan 30;
Non-invasive ventilation in amyotrophic lateral sclerosis.
Vrijsen B, Testelmans D, Belge C, Robberecht W, Van Damme P, Buyse B
Amyotroph Lateral Scler Frontotemporal Degener; 2013 Jan 4;
 

2012

Neuronal overexpression of IP(3) receptor 2 is detrimental in mutant SOD1 mice.
Staats KA, Bogaert E, Hersmus N, Jaspers T, Luyten T, Bultynck G, Parys JB, Hisatsune C, Mikoshiba K, Damme PV, Robberecht W, Bosch LV
Biochem Biophys Res Commun; 2012 Nov 3;
Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency.
Lemmens R, Maugeri A, Niessen HW, Goris A, Tousseyn T, Demaerel P, Corveleyn A, Robberecht W, van der Knaap MS, Thijs VN, Zwijnenburg PJ
Hum Mol Genet; 2012 Oct 12;
H63D polymorphism in HFE is not associated with amyotrophic lateral sclerosis.
van Rheenen W, Diekstra FP, van Doormaal PT, Seelen M, Kenna K, McLaughlin R, Shatunov A, Czell D, van Es MA, van Vught PW, van Damme P, Smith BN, Waibel S, Schelhaas HJ, van der Kooi AJ, de Visser M, Weber M, Robberecht W, Hardiman O, Shaw PJ, Shaw CE, M
Neurobiol Aging; 2012 Oct 11;
Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G93A) mice.
Staats KA, Van Rillaer M, Scheveneels W, Verbesselt R, Van Damme P, Robberecht W, Van Den Bosch L
Neuroscience; 2012 Jun 27;
NIPA1 polyalanine repeat expansions are associated with amyotrophic lateral sclerosis.
Blauw HM, van Rheenen W, Koppers M, Van Damme P, Waibel S, Lemmens R, van Vught PW, Meyer T, Schulte C, Gasser T, Cuppen E, Pasterkamp RJ, Robberecht W, Ludolph AC, Veldink JH, van den Berg LH
Hum Mol Genet; 2012 Feb 28;
Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis.
Herdewyn S, Zhao H, Moisse M, Race V, Matthijs G, Reumers J, Kusters B, Schelhaas HJ, van den Berg LH, Goris A, Robberecht W, Lambrechts D, Van Damme P
Hum Mol Genet; 2012 Feb 17;
Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS.
Diekstra FP, Saris CG, van Rheenen W, Franke L, Jansen RC, van Es MA, van Vught PW, Blauw HM, Groen EJ, Horvath S, Estrada K, Rivadeneira F, Hofman A, Uitterlinden AG, Robberecht W, Andersen PM, Melki J, Meininger V, Hardiman O, Landers JE, Brown RH Jr, S
PLoS One; 2012;7(4):e35333
 

2011

ELP3 Controls Active Zone Morphology by Acetylating the ELKS Family Member Bruchpilot.
MiÅ›kiewicz K, Jose LE, Bento-Abreu A, Fislage M, Taes I, Kasprowicz J, Swerts J, Sigrist S, Versées W, Robberecht W, Verstreken P
Neuron; 2011 Dec 8;72(5):776-88
UNC13A is a modifier of survival in amyotrophic lateral sclerosis.
Diekstra FP, van Vught PW, Rheenen WV, Koppers M, Pasterkamp RJ, van Es MA, Schelhaas HJ, de Visser M, Robberecht W, Van Damme P, Andersen PM, van den Berg LH, Veldink JH
Neurobiol Aging; 2011 Nov 23;
HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease.
d'Ydewalle C, Krishnan J, Chiheb DM, Van Damme P, Irobi J, Kozikowski AP, Berghe PV, Timmerman V, Robberecht W, Van Den Bosch L
Nat Med; 2011 Jul 24;
Response of mouse brain perfusion to hypo- and hyperventilation measured by arterial spin labeling.
Oosterlinck WW, Dresselaers T, Geldhof V, Van Santvoort A, Robberecht W, Herijgers P, Himmelreich U
Magn Reson Med; 2011 Jul 11;
Expanded ATXN2 CAG repeat size in ALS identifies genetic overlap between ALS and SCA2.
Van Damme P, Veldink JH, van Blitterswijk M, Corveleyn A, van Vught PW, Thijs V, Dubois B, Matthijs G, van den Berg LH, Robberecht W
Neurology; 2011 May 11;
TNFRSF1A coding variants in multiple sclerosis.
Goris A, Fockaert N, Cosemans L, Clysters K, Nagels G, Boonen S, Thijs V, Robberecht W, Dubois B
J Neuroimmunol; 2011 May 10;
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease.
Philips T, Robberecht W
Lancet Neurol; 2011 Mar;10(3):253-63
Upper and extra-motoneuron involvement in early motoneuron disease: a diffusion tensor imaging study.
van der Graaff MM, Sage CA, Caan MW, Akkerman EM, Lavini C, Majoie CB, Nederveen AJ, Zwinderman AH, Vos F, Brugman F, van den Berg LH, de Rijk MC, van Doorn PA, Van Hecke W, Peeters RR, Robberecht W, Sunaert S, de Visser M
Brain; 2011 Feb 28;
Benefit of the awaji diagnostic algorithm for amyotrophic lateral sclerosis: A prospective study.
Schrooten M, Smetcoren C, Robberecht W, Van Damme P
Ann Neurol; 2011 Jan 24;
Modeling neurodegenerative diseases in zebrafish embryos.
Laird AS, Robberecht W
Methods Mol Biol; 2011;793:167-84
Unilateral white matter involvement in krabbe disease.
Lemmens R, Piessens F, Demaerel P, Robberecht W
Arch Neurol; 2011 Jan;68(1):130-1
 

2010

Microglial Upregulation of Progranulin as a Marker of Motor Neuron Degeneration.
Philips T, De Muynck L, Thu HN, Weynants B, Vanacker P, Dhondt J, Sleegers K, Schelhaas HJ, Verbeek M, Vandenberghe R, Sciot R, Van Broeckhoven C, Lambrechts D, Van Leuven F, Van Den Bosch L, Robberecht W, Van Damme P
J Neuropathol Exp Neurol; 2010 Dec;69(12):1191-1200
Progranulin is Neurotrophic In Vivo and Protects against a Mutant TDP-43 Induced Axonopathy.
Laird AS, Van Hoecke A, De Muynck L, Timmers M, Van Den Bosch L, Van Damme P, Robberecht W
PLoS One; 2010 Oct 13;5(10)
Mutations in SACS cause atypical and late-onset forms of ARSACS.
Baets J, Deconinck T, Smets K, Goossens D, Van den Bergh P, Dahan K, Schmedding E, Santens P, Rasic VM, Van Damme P, Robberecht W, De Meirleir L, Michielsens B, Del-Favero J, Jordanova A, De Jonghe P
Neurology; 2010 Sep 28;75(13):1181-8
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.
Shatunov A, Mok K, Newhouse S, Weale ME, Smith B, Vance C, Johnson L, Veldink JH, van Es MA, van den Berg LH, Robberecht W, Van Damme P, Hardiman O, Farmer AE, Lewis CM, Butler AW, Abel O, Andersen PM, Fogh I, Silani V, Chiò A, Traynor BJ, Melki J, Meini
Lancet Neurol; 2010 Aug 27;
Mutant HSPB8 causes motor neuron specific neurite degeneration.
Irobi J, Almeida-Souza L, Asselbergh B, De Winter V, Goethals S, Dierick I, Krishnan J, Timmermans JP, Robberecht W, De Jonghe P, Van Den Bosch L, Janssens S, Timmerman V
Hum Mol Genet; 2010 Jun 10;
The neurobiology of amyotrophic lateral sclerosis.
Bento-Abreu A, Van Damme P, Van Den Bosch L, Robberecht W
Eur J Neurosci; 2010 Jun 7;
An unusual presentation of Guillain-Barré syndrome associated with monospecific anti-GD1b antibodies.
Dewil M, Robberecht W, Van Damme P
J Neurol Neurosurg Psychiatry; 2010 May;81(5):587-8
RNA metabolism and the pathogenesis of motor neuron diseases.
Lemmens R, Moore MJ, Al-Chalabi A, Brown RH Jr, Robberecht W
Trends Neurosci; 2010 Mar 11;
Guidelines for preclinical animal research in ALS/MND: A consensus meeting.
Ludolph AC, Bendotti C, Blaugrund E, Chio A, Greensmith L, Loeffler JP, Mead R, Niessen HG, Petri S, Pradat PF, Robberecht W, Ruegg M, Schwalenstöcker B, Stiller D, van den Berg L, Vieira F, von Horsten S
Amyotroph Lateral Scler; 2010;11(1-2):38-45
 

2009

Pathogenic Cysteine Mutations Affect Progranulin Function and Production of Mature Granulins.
Wang J, Van Damme P, Cruchaga C, Gitcho MA, Vidal JM, Seijo-Martínez M, Wang L, Wu JY, Robberecht W, Goate A
J Neurochem; 2009 Dec 17;
The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALS.
Damme PV, Goris A, Race V, Hersmus N, Dubois B, Bosch LV, Matthijs G, Robberecht W
Eur J Neurol; 2009 Nov 13;
Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: a double- blind, randomized, multicentre, placebo-controlled trial.
Meininger V, Drory VE, Leigh PN, Ludolph A, Robberecht W, Silani V
Amyotroph Lateral Scler; 2009 Oct-Dec;10(5-6):378-83
Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis.
Van Es MA, Van Vught PW, Veldink JH, Andersen PM, Birve A, Lemmens R, Cronin S, Van Der Kooi AJ, De Visser M, Schelhaas HJ, Hardiman O, Ragoussis I, Lambrechts D, Robberecht W, Wokke JH, Ophoff RA, Van Den Berg LH
Amyotroph Lateral Scler; 2009 Oct-Dec;10(5-6):441-7
Recent advances in motor neuron disease.
Van Damme P, Robberecht W
Curr Opin Neurol; 2009 Jul 10;
Autosomal recessive spastic ataxia of Charlevoix-Saguenay.
Van Damme P, Demaerel P, Spileers W, Robberecht W
Neurology; 2009 May 19;72(20):1790
Glatiramer acetate has no impact on disease progression in ALS at 40 mg/day: A double- blind, randomized, multicentre, placebo-controlled trial.
Meininger V, Drory VE, Leigh PN, Ludolph A, Robberecht W, Silani V
Amyotroph Lateral Scler; 2009 May 1;:1-7
Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis: Revisited.
Sage CA, Van Hecke W, Peeters R, Sijbers J, Robberecht W, Parizel P, Marchal G, Leemans A, Sunaert S
Hum Brain Mapp; 2009 Apr 29;
Differentiation of hereditary spastic paraparesis from primary lateral sclerosis in sporadic adult-onset upper motor neuron syndromes.
Brugman F, Veldink JH, Franssen H, de Visser M, de Jong JM, Faber CG, Kremer BH, Schelhaas HJ, van Doorn PA, Verschuuren JJ, Bruyn RP, Kuks JB, Robberecht W, Wokke JH, van den Berg LH
Arch Neurol; 2009 Apr;66(4):509-14
Variant on 9p21 strongly associates with coronary heart disease, but lacks association with common stroke.
Lemmens R, Abboud S, Robberecht W, Vanhees L, Pandolfo M, Thijs V, Goris A
Eur J Hum Genet; 2009 Mar 25;
Serum biomarker for progranulin-associated frontotemporal lobar degeneration.
Sleegers K, Brouwers N, Van Damme P, Engelborghs S, Gijselinck I, van der Zee J, Peeters K, Mattheijssens M, Cruts M, Vandenberghe R, De Deyn PP, Robberecht W, Van Broeckhoven C
Ann Neurol; 2009 Mar 13;
TDP-43 M311V mutation in familial amyotrophic lateral sclerosis.
Lemmens R, Race V, Hersmus N, Matthijs G, Van Den Bosch L, Van Damme P, Dubois B, Boonen S, Goris A, Robberecht W
J Neurol Neurosurg Psychiatry; 2009 Mar;80(3):354-5
VEGF protects motor neurons against excitotoxicity by upregulation of GluR2.
Bogaert E, Van Damme P, Poesen K, Dhondt J, Hersmus N, Kiraly D, Scheveneels W, Robberecht W, Van Den Bosch L
Neurobiol Aging; 2009 Jan 28;
Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis.
Van Es MA, Van Vught PW, Veldink JH, Andersen PM, Birve A, Lemmens R, Cronin S, Van Der Kooi AJ, De Visser M, Schelhaas HJ, Hardiman O, Ragoussis I, Lambrechts D, Robberecht W, Wokke JH, Ophoff RA, Van Den Berg LH
Amyotroph Lateral Scler; 2009 Jan 28;:1-12
Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study.
Hermans G, Schrooten M, Van Damme P, Berends N, Bouckaert B, Devooght W, Robberecht W, Van Den Berghe G
Crit Care; 2009 Jan 24;13(1):R5
Peripheral neuropathy and 46XY gonadal dysgenesis: A heterogeneous entity.
Baets J, Dierick I, Groote CC, Ende JV, Martin JJ, Geens K, Robberecht W, Nelis E, Timmerman V, Jonghe PD
Neuromuscul Disord; 2009 Jan 21;
 

2008

Differential contribution of the Na+-K+-2Cl- cotransporter NKCC1 to chloride handling in rat embryonic dorsal root ganglion neurons and motor neurons.
Chabwine JN, Talavera K, Verbert L, Eggermont J, Vanderwinden JM, De Smedt H, Van Den Bosch L, Robberecht W, Callewaert G
FASEB J; 2008 Dec 22;
Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its Ligand VEGF-B in motor neuron degeneration.
Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P
J Neurosci; 2008 Oct 15;28(42):10451-9
Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.
Gowing G, Philips T, Van Wijmeersch B, Audet JN, Dewil M, Van Den Bosch L, Billiau AD, Robberecht W, Julien JP
J Neurosci; 2008 Oct 8;28(41):10234-44
Overexpression of Hsp27 does not influence disease in the mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Krishnan J, Vannuvel K, Andries M, Waelkens E, Robberecht W, Van Den Bosch L
J Neurochem; 2008 Jun 30;
Meta-analysis of VEGF variations in ALS: increased susceptibility in male carriers of the -2578AA genotype.
Lambrechts D, Poesen K, Robberecht W, Fernández-Santiago R, Al-Chalabi A, Del Bo R, Wj Van Vught P, Carmeliet P, Thijs V, Siddique T
J Med Genet; 2008 Apr 15;
Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.
Van Damme P, Van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, Carmeliet P, Van Den Bosch L, Robberecht W
J Cell Biol; 2008 Mar 31;
Relative contribution of mutations in genes for autosomal dominant distal hereditary motor neuropathies: a genotype-phenotype correlation study.
Dierick I, Baets J, Irobi J, Jacobs A, Vriendt ED, Deconinck T, Merlini L, Van den Bergh P, Rasic VM, Robberecht W, Fischer D, Morales RJ, Mitrovic Z, Seeman P, Mazanec R, Kochanski A, Jordanova A, Auer-Grumbach M, Helderman-van den Enden AT, Wokke JH, Ne
Brain; 2008 Mar 5;
Minocycline for patients with ALS.
Leigh PN, Meininger V, Bensimon G, Cudkowicz M, Robberecht W
Lancet Neurol; 2008 Feb;7(2):119-20
Crosstalk between astrocytes and motor neurons: What is the message?
Van Den Bosch L, Robberecht W
Exp Neurol; 2008 Jan 26;
Progranulin genetic variability contributes to amyotrophic lateral sclerosis.
Sleegers K, Brouwers N, Maurer-Stroh S, van Es MA, Van Damme P, van Vught PW, van der Zee J, Serneels S, De Pooter T, Van den Broeck M, Cruts M, Schymkowitz J, De Jonghe P, Rousseau F, van den Berg LH, Robberecht W, Van Broeckhoven C
Neurology; 2008 Jan 9;
 

2007

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.
van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Van Den Bosch L, de Jong SW, de Jong V, Baas F, Van't Slot R, Lemmens R, Schelhaas HJ, Birve A, Sleegers K, Van Broeckhoven C, Schymick JC, Traynor BJ, Wokke JH, Wijmenga C, Robberecht W, Andersen PM,
Nat Genet; 2007 Dec 16;
Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS.
Gijselinck I, Sleegers K, Engelborghs S, Robberecht W, Martin JJ, Vandenberghe R, Sciot R, Dermaut B, Goossens D, van der Zee J, De Pooter T, Del-Favero J, Santens P, De Jonghe P, De Deyn PP, Van Broeckhoven C, Cruts M
Neurobiol Aging; 2007 Dec 7;
Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis.
Dewil M, Lambrechts D, Sciot R, Shaw PJ, Ince PG, Robberecht W, Van Den Bosch L
Neuropathol Appl Neurobiol; 2007 Oct;33(5):499-509
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study.
van Es MA, Van Vught PW, Blauw HM, Franke L, Saris CG, Andersen PM, Van Den Bosch L, de Jong SW, van 't Slot R, Birve A, Lemmens R, de Jong V, Baas F, Schelhaas HJ, Sleegers K, Van Broeckhoven C, Wokke JH, Wijmenga C, Robberecht W, Veldink JH, Ophoff RA,
Lancet Neurol; 2007 Sep 7;
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity.
Van Damme P, Bogaert E, Dewil M, Hersmus N, Kiraly D, Scheveneels W, Bockx I, Braeken D, Verpoorten N, Verhoeven K, Timmerman V, Herijgers P, Callewaert G, Carmeliet P, Van Den Bosch L, Robberecht W
Proc Natl Acad Sci U S A; 2007 Sep 5;
Heterogeneity in motoneuron disease.
Lambrechts D, Robberecht W, Carmeliet P
Trends Neurosci; 2007 Sep 5;
Microglia in amyotrophic lateral sclerosis.
Dewil M, Van Den Bosch L, Robberecht W
Acta Neurol Belg; 2007 Sep;107(3):63-70
Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: Report on the 142nd ENMC international workshop.
Ludolph AC, Bendotti C, Blaugrund E, Hengerer B, Loffler JP, Martin J, Meininger V, Meyer T, Moussaoui S, Robberecht W, Scott S, Silani V, Berg LH, Preclinical EG, Als PO, Models M
Amyotroph Lateral Scler; 2007 Aug;8(4):217-23
Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish.
Lemmens R, Van Hoecke A, Hersmus N, Geelen V, D'Hollander I, Thijs V, Van Den Bosch L, Carmeliet P, Robberecht W
Hum Mol Genet; 2007 Jul 17;
Genetic variant in the HSPB1 promoter region impairs the HSP27 stress response.
Dierick I, Irobi J, Janssens S, Theuns J, Lemmens R, Jacobs A, Corsmit E, Hersmus N, Van Den Bosch L, Robberecht W, De Jonghe P, Van Broeckhoven C, Timmerman V
Hum Mutat; 2007 Jul 10;28(8):830
Progranulin mutations and ALS or ALS-FTD phenotypes.
Schymick J, Yang Y, Andersen P, Vonsattel J, Greenway M, Momeni P, Elder J, Chio A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli R, Hutton M, Gass J, Cannon A, Rademakers R, Singleton A, Hardiman O, Rothstein J, Har
J Neurol Neurosurg Psychiatry; 2007 Mar 19;
Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death.
Dewil M, Dela Cruz VF, Van Den Bosch L, Robberecht W
Neurobiol Dis; 2007 Feb 6;
Role of mitochondria in kainate-induced fast Ca(2+) transients in cultured spinal motor neurons.
Grosskreutz J, Haastert K, Dewil M, Van Damme P, Callewaert G, Robberecht W, Dengler R, Van Den Bosch L
Cell Calcium; 2007 Jan 20;
Chapter 19 Therapies in amyotrophic lateral sclerosis: Options for the near and far future.
Lemmens R, Bosch L, Robberecht W
Handb Clin Neurol; 2007;82:375-87
 

2006

Manofluorographic evaluation of swallowing in amyotrophic lateral sclerosis and its relationship with clinical evaluation of swallowing.
Goeleven A, Robberecht W, Sonies B, Carbonez A, Dejaeger E
Amyotroph Lateral Scler; 2006 Dec;7(4):241-6
Quantitative diffusion tensor imaging in amyotrophic lateral sclerosis.
Sage CA, Peeters RR, Gorner A, Robberecht W, Sunaert S
Neuroimage; 2006 Nov 8;
Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis.
Andries M, Van Damme P, Robberecht W, Van Den Bosch L
Neurobiol Dis; 2006 Oct 11;
Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases.
Bogaert E, Damme PV, Van Den Bosch L, Robberecht W
Muscle Nerve; 2006 Jul 19;
Role of heat shock response and Hsp27 in mutant SOD1-dependent cell death.
Krishnan J, Lemmens R, Robberecht W, Van Den Bosch L
Exp Neurol; 2006 Jun 25;
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis.
Van Den Bosch L, Van Damme P, Bogaert E, Robberecht W
Biochim Biophys Acta; 2006 May 17;
The G93C mutation in superoxide dismutase 1: clinicopathologic phenotype and prognosis.
Regal L, Vanopdenbosch L, Tilkin P, Van den Bosch L, Thijs V, Sciot R, Robberecht W
Arch Neurol; 2006 Feb;63(2):262-7
Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.
Jordanova A, Irobi J, Thomas FP, Van Dijck P, Meerschaert K, Dewil M, Dierick I, Jacobs A, De Vriendt E, Guergueltcheva V, Rao CV, Tournev I, Gondim FA, D'Hooghe M, Van Gerwen V, Callaerts P, Van Den Bosch L, Timmermans JP, Robberecht W, Gettemans J, Thev
Nat Genet; 2006 Jan 22;
Pentoxifylline in ALS: a double-blind, randomized, multicenter, placebo-controlled trial.
Meininger V, Asselain B, Guillet P, Leigh PN, Ludolph A, Lacomblez L, Robberecht W
Neurology; 2006 Jan 10;66(1):88-92
 

2005

Synaptopodin and 4 novel genes identified in primary sensory neurons.
Verpoorten N, Verhoeven K, Weckx S, Jacobs A, Serneels S, Del Favero J, Ceuterick C, Van Bockstaele DR, Berneman ZN, Van Den Bosch L, Robberecht W, Nobbio L, Schenone A, Dessaud E, Delapeyriere O, Huylebroeck D, Zwijsen A, De Jonghe P, Timmerman V
Mol Cell Neurosci; 2005 Aug 31;
The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice.
Petri S, Schmalbach S, Grosskreutz J, Krampfl K, Grothe C, Dengler R, Van Den Bosch L, Robberecht W, Bufler J
J Neurol Sci; 2005 Aug 5;
GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis.
Van Damme P, Braeken D, Callewaert G, Robberecht W, Van Den Bosch L
J Neuropathol Exp Neurol; 2005 Jul;64(7):605-12
Progressive Multifocal Leukoencephalopathy after Natalizumab Therapy for Crohn's Disease.
Van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M, Verbeeck J, Geboes K, Robberecht W, Rutgeerts P
N Engl J Med; 2005 Jun 9;
Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosis.
Dewil M, Schurmans C, Starckx S, Opdenakker G, Van Den Bosch L, Robberecht W
Neuroreport; 2005 Mar 15;16(4):321-4
Report from the Italian Ministerial Committee regarding the diagnosis, care and assistance of patients with ALS.
Bendotti C, Chio A, Congiu ME, De Sanctis Lucentini E, Ferlito E, Garaci E, Massotti M, Mazzini L, Mora G, Oleari F, Robberecht W, Silani V, Taioli E
Amyotroph Lateral Scler Other Motor Neuron Disord; 2005 Mar;6(1)
Reverse transcriptase takes ALS back to viruses.
Robberecht W, Jubelt B
Neurology; 2005 Feb 8;64(3):410-1
Myosin storage myopathy: slow skeletal myosin (MYH7) mutation in two isolated cases.
Laing NG, Ceuterick-de Groote C, Dye DE, Liyanage K, Duff RM, Dubois B, Robberecht W, Sciot R, Martin JJ, Goebel HH
Neurology; 2005 Feb 8;64(3):527-9
Excitotoxicity and amyotrophic lateral sclerosis.
Van Damme P, Dewil M, Robberecht W, Van Den Bosch L
Neurodegener Dis; 2005;2(3-4):147-59
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.
Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H, Van Damme P, Rutten B, Man WY, De Mol M, Wyns S, Manka D, Vermeulen K, Van Den Bosch L, Mertens N, Schmitz C, Robberecht W, Conway EM, Collen D, Moons L, Carmeliet P
Nat Neurosci; 2005 Jan;8(1):85-92
 

2004

Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration.
Van Den Bosch L, Storkebaum E, Vleminckx V, Moons L, Vanopdenbosch L, Scheveneels W, Carmeliet P, Robberecht W
Neurobiol Dis; 2004 Oct;17(1):21-8
Long-lasting changes in GABA responsiveness in cultured neurons.
Chabwine JN, Van Damme P, Eggermont J, De Smedt H, Missiaen L, Van Den Bosch L, Parys JB, Robberecht W, Callewaert G
Neurosci Lett; 2004 Jul 15;365(1):69-72
Efficacy and safety of xaliproden in amyotrophic lateral sclerosis: results of two phase III trials.
Meininger V, Bensimon G, Bradley WR, Brooks B, Douillet P, Eisen AA, Lacomblez L, Leigh PN, Robberecht W
Amyotroph Lateral Scler Other Motor Neuron Disord; 2004 Jun;5(2)
Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy.
Irobi J, Van Impe K, Seeman P, Jordanova A, Dierick I, Verpoorten N, Michalik A, De Vriendt E, Jacobs A, Van Gerwen V, Vennekens K, Mazanec R, Tournev I, Hilton-Jones D, Talbot K, Kremensky I, Van Den Bosch L, Robberecht W, Van Vandekerckhove J, Broeckhov
Nat Genet; 2004 Jun;36(6):597-601
Influence of arterial input function on hypoperfusion volumes measured with perfusion-weighted imaging.
Thijs VN, Somford DM, Bammer R, Robberecht W, Moseley ME, Albers GW
Stroke; 2004 Jan;35(1):94-8
 

2003

Hypersensitivity pneumonitis possibly caused by riluzole therapy in ALS.
Cassiman D, Thomeer M, Verbeken E, Robberecht W
Neurology; 2003 Oct 28;61(8):1150-1
Skeletal muscle properties in a transgenic mouse model for amyotrophic lateral sclerosis: effects of creatine treatment.
Derave W, Van Den Bosch L, Lemmens G, Eijnde BO, Robberecht W, Hespel P
Neurobiol Dis; 2003 Aug;13(3):264-72
A case of hemiparesis associated with cranial nerve lesions due to intravascular lymphomatosis(2003:4b).
De Bruecker Y, Demaerel P, Wilms G, Sciot R, Ballaux F, Robberecht W
Eur Radiol; 2003 Jul;13(7):1753-5
Chloride influx aggravates Ca2+-dependent AMPA receptor-mediated motoneuron death.
Van Damme P, Callewaert G, Eggermont J, Robberecht W, Van Den Bosch L
J Neurosci; 2003 Jun 15;23(12):4942-50
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Van Damme P, Leyssen M, Callewaert G, Robberecht W, Van Den Bosch L
Neurosci Lett; 2003 Jun 5;343(2):81-4
Coexistence of CADASIL and Alzheimer's disease.
Thijs V, Robberecht W, De Vos R, Sciot R
J Neurol Neurosurg Psychiatry; 2003 Jun;74(6):790-2
Accuracy of diffusion-weighted MR imaging in the diagnosis of sporadic Creutzfeldt-Jakob disease.
Demaerel P, Sciot R, Robberecht W, Dom R, Vandermeulen D, Maes F, Wilms G
J Neurol; 2003 Feb;250(2):222-5
 

2002

Upregulation of HSP27 in a transgenic model of ALS.
Vleminckx V, Van Damme P, Goffin K, Delye H, Van Den Bosch L, Robberecht W
J Neuropathol Exp Neurol; 2002 Nov;61(11):968-74
GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity.
Van Damme P, Van Den Bosch L, Van Houtte E, Callewaert G, Robberecht W
J Neurophysiol; 2002 Sep;88(3):1279-87
Na(+) entry through AMPA receptors results in voltage-gated k(+) channel blockade in cultured rat spinal cord motoneurons.
Van Damme P, Van Den Bosch L, Van Houtte E, Eggermont J, Callewaert G, Robberecht W
J Neurophysiol; 2002 Aug;88(2):965-72
CuZn-superoxide dismutase in D90A heterozygotes from recessive and dominant ALS pedigrees.
Jonsson PA, Backstrand A, Andersen PM, Jacobsson J, Parton M, Shaw C, Swingler R, Shaw PJ, Robberecht W, Ludolph AC, Siddique T, Skvortsova VI, Marklund SL
Neurobiol Dis; 2002 Aug;10(3):327-33
Minocycline delays disease onset and mortality in a transgenic model of ALS.
Van Den Bosch L, Tilkin P, Lemmens G, Robberecht W
Neuroreport; 2002 Jun 12;13(8):1067-70
Cardiac involvement and CTG expansion in myotonic dystrophy.
Merlevede K, Vermander D, Theys P, Legius E, Ector H, Robberecht W
J Neurol; 2002 Jun;249(6):693-8
Protective effect of parvalbumin on excitotoxic motor neuron death.
Van Den Bosch L, Schwaller B, Vleminckx V, Meijers B, Stork S, Ruehlicke T, Van Houtte E, Klaassen H, Celio MR, Missiaen L, Robberecht W, Berchtold MW
Exp Neurol; 2002 Apr;174(2):150-61
An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition.
Van den Bosch L, Van Damme P, Vleminckx V, Van Houtte E, Lemmens G, Missiaen L, Callewaert G, Robberecht W
Neuropharmacology; 2002 Apr;42(5):706-13
[A man with plasma cell dyscrasia and polyneuropathy due to POEMS syndrome]
Driessens SK, Wildiers H, Verhoef GE, Vanstraelen D, Robberecht W, Vandenberghe P
Ned Tijdschr Geneeskd; 2002 Feb 16;146(7):321-5
 

2001

Subcellular localization of calcium-permeable AMPA receptors in spinal motoneurons.
Vandenberghe W, Bindokas VP, Miller RJ, Robberecht W, Brorson JR
Eur J Neurosci; 2001 Jul;14(2):305-14
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.
Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, Van Dorpe J, Hellings P, Gorselink M, Heymans S, Vermylen P, Raat H, Acker T, Vleminckx V, Van Den Bosch L, Sciot R, Robberecht W, Herbert JM, Collen D, Carmeliet P, ...
Nat Genet; 2001 Jun;28(2):131-8
Amyotrophic lateral sclerosis: pathogenesis.
Brown RH Jr, Robberecht W
Semin Neurol; 2001 Jun;21(2):131-9
 

2000

Genetics of amyotrophic lateral sclerosis.
Robberecht W
J Neurol; 2000 Dec;247:2-6
Genetics of amyotrophic lateral sclerosis.
Robberecht W
J Neurol; 2000 Dec;247 Suppl 6:VI/2-6
Different receptors mediate motor neuron death induced by short and long exposures to excitotoxicity.
Van Den Bosch L, Robberecht W
Brain Res Bull; 2000 Nov 1;53(4):383-8
Preface
Leigh PN, Robberecht W
J Neurol Sci; 2000 Nov 1;180(1-2):1
Ca(2+)-permeable AMPA receptors and selective vulnerability of motor neurons.
Van Den Bosch L, Vandenberghe W, Klaassen H, Van Houtte E, Robberecht W
J Neurol Sci; 2000 Nov 1;180(1-2):29-34
AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability.
Vandenberghe W, Ihle EC, Patneau DK, Robberecht W, Brorson JR
J Neurosci; 2000 Oct 1;20(19):7158-66
Amyotrophic lateral sclerosis: pathogenesis.
Robberecht W, Van Den Bosch L, Vleminckx V
Acta Neurol Belg; 2000 Sep;100(3):181-7
Abnormal intracellular ca(2+)homeostasis and disease.
Missiaen L, Robberecht W, van den Bosch L, Callewaert G, Parys JB, Wuytack F, Raeymaekers L, Nilius B, Eggermont J, De Smedt H
Cell Calcium; 2000 Jul;28(1):1-21
Demographic characteristics and prognosis in a Flemish amyotrophic lateral sclerosis population.
Thijs V, Peeters E, Theys P, Matthijs G, Robberecht W
Acta Neurol Belg; 2000 Jun;100(2):84-90
Genetic markers of ALS.
Robberecht W
Amyotroph Lateral Scler Other Motor Neuron Disord; 2000 Jun;1 Su
Oxidative stress in amyotrophic lateral sclerosis.
Robberecht W
J Neurol; 2000 Mar;247 Suppl 1:I1-6
AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability.
Vandenberghe W, Robberecht W, Brorson JR
J Neurosci; 2000 Jan 1;20(1):123-32
 

1999

Mutational analysis of the Cu/Zn superoxide dismutase gene in 23 familial and 69 sporadic cases of amyotrophic lateral sclerosis in Belgium.
Aguirre T, Matthijs G, Robberecht W, Tilkin P, Cassiman JJ
Eur J Hum Genet; 1999 Jul;7(5):599-602
A retrospective study of Creutzfeldt-Jakob disease in Belgium.
Pals P, Van Everbroeck B, Sciot R, Godfraind C, Robberecht W, Dom R, Laterre C, Martin JJ, Cras P
Eur J Epidemiol; 1999 Jul;15(6):517-9
Evolution of motor and sensory deficits in amyotrophic lateral sclerosis estimated by neurophysiological techniques.
Theys PA, Peeters E, Robberecht W
J Neurol; 1999 Jun;246(6):438-42
Intravascular lymphomatosis of the brain: a diagnostic problem.
Vieren M, Sciot R, Robberecht W
Clin Neurol Neurosurg; 1999 Mar;101(1):33-6
A novel 7.4 kb mitochondrial deletion in a patient with congenital progressive external ophthalmoplegia, muscle weakness and mental retardation.
Tabaku M, Legius E, Robberecht W, Sciot R, Fryns JP, Cassiman JJ, Matthijs G
Genet Couns; 1999;10(3):285-93
Calcium handling proteins in isolated spinal motoneurons.
Van Den Bosch L, Verhoeven K, De Smedt H, Wuytack F, Missiaen L, Robberecht W
Life Sci; 1999;65(15):1597-606
Diffusion-weighted MRI in sporadic Creutzfeldt-Jakob disease.
Demaerel P, Heiner L, Robberecht W, Sciot R, Wilms G
Neurology; 1999 Jan 1;52(1):205-8
 

1998

Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor.
Al-Chalabi A, Andersen PM, Chioza B, Shaw C, Sham PC, Robberecht W, Matthijs G, Camu W, Marklund SL, Forsgren L, Rouleau G, Laing NG, Hurse PV, Siddique T, Leigh PN, Powell JF
Hum Mol Genet; 1998 Dec;7(13):2045-50
Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system.
Vandenberghe W, Van Den Bosch L, Robberecht W
Brain Res; 1998 Oct 5;807(1-2):1-10
Tissue-type plasminogen activator is not required for kainate-induced motoneuron death in vitro.
Vandenberghe W, Van Den Bosch L, Robberecht W
Neuroreport; 1998 Aug 24;9(12):2791-6
A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. European ALS/IGF-I Study Group.
Borasio GD, Robberecht W, Leigh PN, Emile J, Guiloff RJ, Jerusalem F, Silani V, Vos PE, Wokke JH, Dobbins T
Neurology; 1998 Aug;51(2):583-6
Increased sensitivity of fibroblasts from amyotrophic lateral sclerosis patients to oxidative stress.
Aguirre T, Van Den Bosch L, Goetschalckx K, Tilkin P, Mathijs G, Cassiman JJ, Robberecht W
Ann Neurol; 1998 Apr;43(4):452-7
 

1997

Mibefradil (Ro 40-5967) blocks multiple types of voltage-gated calcium channels in cultured rat spinal motoneurones.
Viana F, Van den Bosch L, Missiaen L, Vandenberghe W, Droogmans G, Nilius B, Robberecht W
Cell Calcium; 1997 Oct;22(4):299-311
Copper and zinc levels in familial amyotrophic lateral sclerosis patients with CuZnSOD gene mutations.
Radunovic A, Delves HT, Robberecht W, Tilkin P, Enayat ZE, Shaw CE, Stevic Z, Apostolski S, Powell JF, Leigh PN
Ann Neurol; 1997 Jul;42(1):130-1
Diffusion-weighted magnetic resonance imaging in Creutzfeldt-Jakob disease.
Demaerel P, Baert AL, Vanopdenbosch L, Robberecht W, Dom R
Lancet; 1997 Mar 22;349(9055):847-8
Familial juvenile focal amyotrophy of the upper extremity (Hirayama disease). Superoxide dismutase 1 genotype and activity.
Robberecht W, Aguirre T, Van den Bosch L, Theys P, Nees H, Cassiman JJ, Matthijs G
Arch Neurol; 1997 Jan;54(1):46-50
 

1996

D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis.
Robberecht W, Aguirre T, Van den Bosch L, Tilkin P, Cassiman JJ, Matthijs G
Neurology; 1996 Nov;47(5):1336-9
Lymphocytic infundibulohypophysitis presenting in the postpartum period: case report.
Van Havenbergh T, Robberecht W, Wilms G, Van Calenbergh F, Goffin J, Dom R, Bouillon R, Plets C
Surg Neurol; 1996 Sep;46(3):280-4
Pathological findings in a patient with amyotrophic lateral sclerosis and multifocal motor neuropathy with conduction block.
Veugelers B, Theys P, Lammens M, Van Hees J, Robberecht W
J Neurol Sci; 1996 Mar;136(1-2):64-70
Neurofibromatosis type I gene mutation in a patient with features of LEOPARD syndrome.
Wu R, Legius E, Robberecht W, Dumoulin M, Cassiman JJ, Fryns JP
Hum Mutat; 1996;8(1):51-6
Molecular genetic analysis of the 17p11.2 region in patients with hereditary neuropathy with liability to pressure palsies (HNPP).
Timmerman V, Lofgren A, Le Guern E, Liang P, De Jonghe P, Martin JJ, Verhalle D, Robberecht W, Gouider R, Brice A, Van Broeckhoven C
Hum Genet; 1996 Jan;97(1):26-34
 

1995

Distal myopathy as the presenting manifestation of sarcoidosis.
Robberecht W, Theys P, Lammens M, Leenders J
J Neurol Neurosurg Psychiatry; 1995 Dec;59(6):642-3
Focal leptomeningeal MR enhancement along the chiasm as a presenting sign of multiple sclerosis.
Demaerel P, Robberecht W, Casteels I, Wilms G, Medaer R, Carton H, Baert AL
J Comput Assist Tomogr; 1995 Mar-Apr;19(2):297-8
Neurocysticercosis: a poorly understood disease.
Vantomme M, Swartenbroekx R, Dhaen B, Peetermans W, Plets C, Demaerel P, Dom R, Robberecht W
Acta Neurol Belg; 1995;95(1):23-8
New treatment strategies in amyotrophic lateral sclerosis: solutions or illusions?
Robberecht W
Acta Neurol Belg; 1995;95(2):65-9
 

1994

Deletion in the CMT1A locus on chromosome 17p11.2 in hereditary neuropathy with liability to pressure palsies.
Verhalle D, Lofgren A, Nelis E, Dehaene I, Theys P, Lammens M, Dom R, Van Broeckhoven C, Robberecht W
Ann Neurol; 1994 Jun;35(6):704-8
Cu/Zn superoxide dismutase activity in familial and sporadic amyotrophic lateral sclerosis.
Robberecht W, Sapp P, Viaene MK, Rosen D, McKenna-Yasek D, Haines J, Horvitz R, Theys P, Brown R Jr
J Neurochem; 1994 Jan;62(1):384-7
 

1993

Meningitis due to Neisseria meningitidis with intermediate susceptibility to penicillin.
Brunen A, Peetermans W, Verhaegen J, Robberecht W
Eur J Clin Microbiol Infect Dis; 1993 Dec;12(12):969-70
 

1992

Lack of improvement with ceftriaxone in motoneuron disease.
Robberecht W
Lancet; 1992 Oct 31;340(8827):1096-7
Angiotensin II is retained in gonadotrophs of pituitary cell aggregates cultured in serum-free medium but does not mimic the effects of exogenous angiotensins and luteinizing-hormone-releasing hormone on growth hormone release.
Robberecht W, Andries M, Denef C
Neuroendocrinology; 1992 Oct;56(4):550-60
Stimulation of prolactin secretion from rat pituitary by luteinizing hormone-releasing hormone: evidence against mediation by angiotensin II acting through a (Sar1-Ala8)-angiotensin II-sensitive receptor.
Robberecht W, Andries M, Denef C
Neuroendocrinology; 1992 Aug;56(2):185-94
Purulent meningitis due to aspergillosis in a patient with systemic lupus erythematosus.
Lammens M, Robberecht W, Waer M, Carton H, Dom R
Clin Neurol Neurosurg; 1992;94(1):39-43
MRI of herpes simplex encephalitis.
Demaerel P, Wilms G, Robberecht W, Johannik K, Van Hecke P, Carton H, Baert AL
Neuroradiology; 1992;34(6):490-3
 

1990

Evidence for a pertussis toxin-sensitive signalling pathway in the dual action of angiotensin II on growth hormone release in pituitary cell aggregates.
Robberecht W, Denef C
Cell Biol Int Rep; 1990 Nov;14(11):1001-11
 

1989

MRI of transverse sinus thrombosis.
Demaerel P, Wilms G, Marchal G, van Hecke P, Robberecht W, Baert AL
Rofo; 1989 Sep;151(3):386-7
Myasthenic syndrome caused by direct effect of chloroquine on neuromuscular junction.
Robberecht W, Bednarik J, Bourgeois P, van Hees J, Carton H
Arch Neurol; 1989 Apr;46(4):464-8
Cell-to-cell communication in peptide target cells of anterior pituitary.
Denef C, Maertens P, Allaerts W, Mignon A, Robberecht W, Swennen L, Carmeliet P
Methods Enzymol; 1989;168:47-71
 

1988

Enhanced ANG II activity in anterior pituitary cell aggregates from hypertensive rats.
Robberecht W, Denef C
Am J Physiol; 1988 Sep;255(3 Pt 2):R407-11
Stimulation and inhibition of pituitary growth hormone release by angiotensin II in vitro.
Robberecht W, Denef C
Endocrinology; 1988 Apr;122(4):1496-504
Painful muscle spasms complicating algodystrophy: central or peripheral disease?
Robberecht W, Van Hees J, Adriaensen H, Carton H
J Neurol Neurosurg Psychiatry; 1988 Apr;51(4):563-7