About us

Our research focuses on the cognitive domains selective attention, language and semantic memory.

Our approach is characterized by the integration of studies in different populations. We derive functional-anatomical models on the basis of fMRI in cognitively intact controls and test the predictions of these models in patients with structural and functional lesions, both cross-sectionally and longitudinally.

The populations that we study are cognitive aging, cortical neurodegenerative disease and unifocal cortical stroke.

A second characteristic of our experimental approach is the integration of different levels of dysfunction: cognitive performance, changes in cognitive brain systems measured with fMRI, and PET imaging of pathogenetic processes such as amyloid deposition and cholinergic depletion.

Interventions that affect these different levels are in development and our convergent approach lays the foundation for direct in vivo imaging of the effect of these interventions before they are applied in large-scale clinical trials.